Publications

Self-organized flows in phase-synchronizing active fluids
Many active biological particles, such as swimming microorganisms or motor-proteins, do work on their environment by going though a …
Brato Chakrabarti, Michael J Shelley, Sebastian Fürthauer
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Spontaneous phase coordination and fluid pumping in model ciliary carpets
Ciliated tissues such as in the mammalian lungs, brains, and reproductive tracts, are specialized to pump fluid. They generate flows by …
Anup Kanale, Feng Ling, Hanliang Guo, Sebastian Fürthauer, Eva Kanso
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Spontaneous phase coordination and fluid pumping in model ciliary carpets
How Cross-Link Numbers Shape the Large-Scale Physics of Cytoskeletal Materials
Cytoskeletal networks are the main actuators of cellular mechanics, and a foundational example for active matter physics. In …
Sebastian Fürthauer, Michael J Shelley
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How Cross-Link Numbers Shape the Large-Scale Physics of Cytoskeletal Materials
A multiscale biophysical model gives quantized metachronal waves in a lattice of beating cilia
Understanding the emergence and properties of metachronal waves (MWs) in ciliary arrays is a multiscale problem central to …
Brato Chakrabarti, Sebastian Fürthauer, Michael J Shelley
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A multiscale biophysical model gives quantized metachronal waves in a lattice of beating cilia
Microtubule reorganization during female meiosis in C. elegans
Most female meiotic spindles undergo striking morphological changes while transitioning from metaphase to anaphase. The ultra-structure …
Ina Lantzsch, Che-Hang Yu, Yu-Zen Chen, Vitaly Zimyanin, Hossein Yazdkhasti, Norbert Lindow, Erik Szentgyoergyi, Ariel M Pani, Steffen Prohaska, Martin Srayko, Sebastian Fürthauer, Stefanie Redemann
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Microtubule reorganization during female meiosis in C. elegans
A hydraulic instability drives the cell death decision in the nematode germline
Oocytes are large cells that develop into an embryo upon fertilization1. As interconnected germ cells mature into oocytes, some of them …
Nicolas T Chartier, Arghyadip Mukherjee, Julia Pfanzelter, Sebastian Fürthauer, Ben T Larson, Anatol W Fritsch, Rana Amini, Moritz Kreysing, Frank Jülicher, Stephan W Grill
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A hydraulic instability drives the cell death decision in the nematode germline
A design framework for actively crosslinked filament networks
Living matter moves, deforms, and organizes itself. In cells this is made possible by networks of polymer filaments and crosslinking …
Sebastian Fürthauer, Daniel J Needleman, Michael J Shelley
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A design framework for actively crosslinked filament networks
Co-movement of astral microtubules, organelles and F-actin suggests aster positioning by surface forces in frog eggs
How bulk cytoplasm generates forces to separate post-anaphase microtubule (MT) asters in Xenopus laevis and other large eggs remains …
James F Pelletier, Christine M Field, Sebastian Fürthauer, Matthew Sonnett, Timothy J Mitchison
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Co-movement of astral microtubules, organelles and F-actin suggests aster positioning by surface forces in frog eggs
Self-straining of actively crosslinked microtubule networks
Cytoskeletal networks are foundational examples of active matter and central to self-organized structures in the cell. In vivo, these …
Sebastian Fürthauer, Bezia Lemma, Peter Foster, Stephanie Ems-McClung, Che-Hang Yu, Claire Wlaczak, Zvonimir Dogic, Daniel Needleman, Michael Shelley
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Self-straining of actively crosslinked microtubule networks
From cytoskeletal assemblies to living materials
The cellular cytoskeleton is an active material, driven out of equilibrium by molecular motor proteins. It is not understood how the …
Peter J Foster, Sebastian Fürthauer, Michael J Shelley, Daniel J Needleman
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From cytoskeletal assemblies to living materials
Current approaches for the analysis of spindle organization
The organization of microtubules in spindles is complex and not fully understood. Here we report on current advances in generating 3D …
Stefanie Redemann, Sebastian Fürthauer, Michael Shelley, Thomas Müller-Reichert
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Current approaches for the analysis of spindle organization
Morphogenetic degeneracies in the actomyosin cortex
One of the great challenges in biology is to understand the mechanisms by which morphogenetic processes arise from molecular …
Sundar Ram Naganathan, Sebastian Fürthauer, Josana Rodriguez, Bruno Thomas Fievet, Frank Jülicher, Julie Ahringer, Carlo Vittorio Cannistraci, Stephan W Grill
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Measuring and modeling polymer concentration profiles near spindle boundaries argues that spindle microtubules regulate their own nucleation
Bryan Kaye, Olivia Stiehl, Peter J Foster, Michael J Shelley, Daniel J Needleman, Sebastian Fürthauer
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Measuring and modeling polymer concentration profiles near spindle boundaries argues that spindle microtubules regulate their own nucleation
Connecting macroscopic dynamics with microscopic properties in active microtubule network contraction
The cellular cytoskeleton is an active material, driven out of equilibrium by molecular motor proteins. It is not understood how the …
Peter J Foster, Wen Yan, Sebastian Fürthauer, Michael J Shelley, Daniel J Needleman
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Connecting macroscopic dynamics with microscopic properties in active microtubule network contraction
C. elegans chromosomes connect to centrosomes by anchoring into the spindle network
The mitotic spindle ensures the faithful segregation of chromosomes. Here we combine the first large-scale serial electron tomography …
Stefanie Redemann, Johannes Baumgart, Norbert Lindow, Michael Shelley, Ehssan Nazockdast, Andrea Kratz, Steffen Prohaska, Jan Brugués, Sebastian Fürthauer, Thomas Müller-Reichert
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C. elegans chromosomes connect to centrosomes by anchoring into the spindle network
Actomyosin-driven left-right asymmetry: from molecular torques to chiral self organization
Chirality or mirror asymmetry is a common theme in biology found in organismal body plans, tissue patterns and even in individual …
Sundar Ram Naganathan, Teije C Middelkoop, Sebastian Fürthauer, Stephan W Grill
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Active contraction of microtubule networks
Many cellular processes are driven by cytoskeletal assemblies. It remains unclear how cytoskeletal filaments and motor proteins …
Peter J Foster, Sebastian Fürthauer, Michael J Shelley, Daniel J Needleman
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Active contraction of microtubule networks
Active torque generation by the actomyosin cell cortex drives left--right symmetry breaking
Many developmental processes break left–right (LR) symmetry with a consistent handedness. LR asymmetry emerges early in development, …
Sundar Ram Naganathan, Sebastian Fürthauer, Masatoshi Nishikawa, Frank Jülicher, Stephan W Grill
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Active torque generation by the actomyosin cell cortex drives left--right symmetry breaking
Phase-synchronized state of oriented active fluids
We present a theory for self-driven fluids, such as motorized cytoskeletal extracts or microbial suspensions, that takes into account …
Sebastian Fürthauer, Sriram Ramaswamy
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Phase-synchronized state of oriented active fluids
Active chiral processes in thin films
We develop a generic description of thin active films that captures key features of flow and rotation patterns emerging from the …
Sebastian Fürthauer, M Strempel, Stephan W Grill, Frank Jülicher
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Active chiral processes in thin films
The Taylor--Couette motor: spontaneous flows of active polar fluids between two coaxial cylinders
We study the dynamics of active polar fluids in a Taylor–Couette geometry where the fluid is confined between two rotating coaxial …
Sebastian Fürthauer, Marc Neef, Stefan W Grill, Karsten Kruse, Frank Jülicher
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The Taylor--Couette motor: spontaneous flows of active polar fluids between two coaxial cylinders
Active chiral fluids
Active processes in biological systems often exhibit chiral asymmetries. Examples are the chirality of cytoskeletal filaments which …
Sebastian Fürthauer, M Strempel, Stephan W Grill, Frank Jülicher
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Transient localization in the kicked Rydberg atom
Emil Persson, Sebastian Fürthauer, S Wimberger, Joachim Burgdörfer
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